PhD student (OIO)/Postdoc
The Netherlands Cancer Institute (NKI-AVL)
We have obtained a large number of MMTV induced mammary tumors from the Balb/c mouse strain, a p53 conditional knockout strain and ErbB2 transgenic strains. The mammary tumors are being screened for MMTV insertion sites and the putative oncogenes that are activated have already been identified while other may be identified in future experiments. An important aspect of the project is to confirm the transforming capacity of the candidate oncogenes and investigate how these genes collaborate in vivo using genetically modified mice.
Next, the regulatory pathways these oncogenes are acting in, will be studied using biochemical and cell biological techniques. A recent publication from this work: Theodorou et al., MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer. Nat Genet. 2007;39:759-769. The Postdoc should have a strong background in molecular biology and some training in cell biology. The PhD student and Postdoc should have an interest in research focused on both fundamental and clinically relevant aspects of tumorigenesis. Experience with mouse models will be appreciated.See also: http://www.nki.nl/Research/Faculty+and+Research/Divisions/Molecular+Genetics/Hilkens.htm
Requirements
We are looking for a highly motivated and enthusiastic PhD student with a university degree (MSc.) in biology medical biology or biochemistry, an extensive training in molecular biology and some experience in cell biology. The Postdoc should have a strong background in molecular biology and some training in cell biology. The PhD student and Postdoc should have an interest in research focused on both fundamental and clinically relevant aspects of tumorigenesis. Experience with mouse models will be appreciated.
Conditions of employment
The temporary employment for the PhD student will be for a period of 4 years and for the Postdoc for a period of 3 years. The gross monthly salary for a PhD student will range from 2354 to 2899 according to the PhD scales, depending on previous experience. The gross monthly salary for a Postdoc will range from 2593 to 3460 according to function scale FWG 55 and depends on previous experience. The terms of employment will be in accordance with the Collective Labour Agreement for Hospitals (CAO Ziekenhuizen). Beside these working conditions the NKI-AVL offers an excellent atmosphere in a specialized hospital. Not for nothing the NKI-AVL has been listed in 2009 top 25 of Best Employers.
Contract type
Temporary
3 or 4 years
Additional information
For more information please contact Dr J. Hilkens, project leader, tel.: (+31) (0)20 512 2018, e-mail: nki.nl">j.hilkensatnki.nl or look at our website: www.nki.nl.
To apply for this position, visit AcademicTransfer for the original posting, and many other PhD vacancies.
Job Title PhD student (OIO)/Postdoc
POST DETAILS
Org Name The Netherlands Cancer Institute (NKI-AVL)
Contact Person Dr J. Hilkens
Tel (+31) (0)20 512 2018
Fax
E-Mail j.hilkensnki.nl
City Amsterdam
State/Province N
Country Netherlands
