ESRC Studentships, Imperial College London, Division of Epidemiology, Public Health and Primary Care : St Marys Paddington or South Kensington

Science jobs from Imperial College London: job description

Division of Epidemiology, Public Health and Primary Care
UK/EU PhD Studentships

3-year UK/EU PhD Studentships (ESRC funded)
The Division has four 3-year ESRC studentships for candidates who wish to undertake projects within the ESRC remit of ‘social statistics, research methods and computing’ which is defined at: http://www.esrcsocietytoday.ac.uk/ESRCInfoCentre/opportunities/postgraduate/fundingopportunities/.

>Examples of previous ESRC studentships within the Division include:

• Aetiology of Gua Kua: A newly indentified liver disease in the Tigray region of Ethiopia
• Genetic association analysis from a life-course perspective in the Northern Finland Birth Cohort 1966

Candidates should have completed an ESRC recognised masters course or equivalent. The studentship includes full payment of tuition fees and an enhanced stipend of £17,000. Owing to funding restrictions these studentships are open to UK nationals or EU nationals, who have lived in the UK for at least three years immediately preceding the date of the award. For full eligibility requirements please refer to; http://www.esrc.ac.uk/ESRCInfoCentre/Images/GUIDANCE%20NOTES%20FOR%20APPLICANTS%202008_tcm6-7186.pdf

All students will belong to the Graduate School of Life Sciences and Medicine which provides a full programme of training in research and transferable skills. Students will be based in the Department of Epidemiology & Public Health, Infectious Disease Epidemiology, or Primary Care & Social Medicine within the Division of EPHPC. Further details of the Division can be found at http://www1.imperial.ac.uk/medicine/about/divisions/ephpc/

You should send one hard copy and an electronic version, of a full CV, including two original references, and a letter stating why you are interested in pursuing postgraduate study in the Division of EPHPC to Catherine England, EPHPC, Imperial College London, Norfolk Place, London, W2 1PG.

Please note that candidates must fulfil College admissions criteria. For an informal discussion please contact Professor Marjo-Riitta Jarvelin, tel: +44 (0) 207 594 3345 or +44 (0)7725 414367, email: m.jarvelin@imperial.ac.uk.

It is estimated that interviews will be held between 11th – 13th March 2009

Closing date for applications: 9th March 2009
Valuing diversity and committed to equality of opportunities

Imperial College London, Division of Epidemiology, Public Health and Primary Care, 1 +3 Studentship : St Marys

Science jobs from Imperial College London: job description

Division of Epidemiology, Public Health and Primary Care

One 1 + 3 PhD Studentship is available commencing October 2009

The Division of Epidemiology, Public Health and Primary Care is seeking highly motivated applicants, with a degree in a relevant discipline, for a 1 plus 3 year PhD programme in either the Department of Epidemiology & Public Health; Infectious Disease Epidemiology or Primary Care & Social Medicine.

The studentship is funded by the Division for either a one–year MSc in Modern Epidemiology or a Masters in Public Health (MPH) followed by a three-year PhD programme. Progress to the PhD is subject to performance. The studentships include full payment of Home/EU fees and an enhanced stipend of £17,000. Owing to funding restrictions applications from non-Home/EU candidates cannot be considered for this post.

For details of the MSc and MPH please refer to the following website:
http://www1.imperial.ac.uk/medicine/about/divisions/ephpc/postgrad/taughtcourses/

The Division currently has a strong doctoral programme with over 60 PhD students carrying out research in the areas of Infectious Disease Epidemiology, Chronic Disease Epidemiology, Primary Care and Health Services Research. Please visit our divisional website for further details of the research carried out within the Division.
http://www1.imperial.ac.uk/medicine/about/divisions/ephpc/postgrad/default.html

You should send one hard copy and an electronic version, of a full CV, including two original references, and a letter stating why you are interested in pursuing postgraduate study in the Division of EPHPC to Catherine England, EPHPC, Imperial College London, Norfolk Place, London, W2 1PG.

Please note that candidates must fulfil College admissions criteria. For an informal discussion please contact Professor Marjo-Riitta Jarvelin, tel: 0207 594 3345 or 07976 882438, email: m.jarvelin@imperial.ac.uk.

It is estimated that interviews will be held between 11th – 13th March 2009

Closing date for applications: 9th March 2009

Valuing diversity and committed to equality of opportunities

4 year PhD studentship in Immunolgy : Babraham, Cambridge, CB22 3AT

Science jobs from Babraham Institute: job description

A 4 year BBSRC CASE studentship is available to investigate the role of PI3K in T helper cell differentiation and cytokine secretion. To be eligible, you need to be a UK resident or EU national and to meet the criteria for dmission to the University of Cambridge Graduate School which include obtaining a first or upper second class BSc degree or equivalent. The ideal candidate will have a degree in biological sciences including a significant immunology component.

The student will also spend a proportion of the time at GSK in Stevenage. In addition, GSK will pay £3000 in addition to the standard BBSRC annual stipend. EU residents may need to apply for additional funding (see http://www.babraham.ac.uk/graduate/funding.htm for details).

Informal inquiries can be addressed to Dr Klaus Okkenhaug (klaus.okkenhaug@bbsrc.ac.uk).

Project description:

Regulation of T helper cell differentiation, cytokine expression and secretion by PI3K

CD4 helper T cells that have never been exposed to cognate antigens are referred to as naïve or virgin T cells. Naïve T cells require costimulation for their activation and can within hours produce the cytokine interleukin 2. Subsequently, and depending on cytokines present during the initial stimulation, naïve T cells differentiate to adopt effector phenotypes which are classified as distinct Th or regulatory T cell lineages based on the combination of transcription factors they express and the types of cytokines they can secrete. Initially, a simple model prevailed where T cells either differentiated to IFN-γ secreting Th1 cells or IL-4 secreting Th2 cells.

PI3Ks are intracellular lipid kinases that generate second messenger signalling molecules which control growth, proliferation, differentiation and migration. We have shown that p110δ(D910A) mice, in which the p110δ PI3K catalytic subunit has been inactivated by point mutation, are resistant to differentiate and produce less effector cytokines such as IL-4 or IFN-γ (Okkenhaug et al 2006; Patton et al 2007).

While the Th1/Th2 dichotomy model has been extremely useful in identifying the principles, signalling pathways, transcription factors and epigenetic changes that control T cell differentiation, the model has been wholly inadequate in explaining the complexity of immune responses to pathogens or how autoimmune diseases develop. We now know that naïve T cells can adopt at least 5 different well-defined lineages (Th1, Th2, Th17, Tfh and Treg) and more are likely to be discovered. The student will elucidate precise roles played by p110δ in regulating Th cell differentiation and cytokine expression, both by extending our previous observations and by investigating the effect of PI3K inhibition on the development of new Th subsets.

These studies should provide novel insights into how a conserved signalling pathway can be exploited by T cells to fine-tune immune responses against diverse pathogenic micro-organisms.

References

Okkenhaug, K., D. T. Patton, A. Bilancio, F. Garcon, W. C. Rowan, and B. Vanhaesebroeck. 2006. The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells. J Immunol 177:5122-5128.
http://www.jimmunol.org/cgi/content/abstract/177/8/5122

Patton, D. T., F. Garcon, and K. Okkenhaug. 2007. The PI3K p110δ controls T-cell development, differentiation and regulation. Biochem Soc Trans 35:167-171.
http://www.biochemsoctrans.org/bst/035/bst0350167.htm

Centre for Obesity Research 4-Year PhD Studentships : Birmingham, UK

Applications are invited for 4-year PhD studentships within the Centre for Obesity Research (www.obesity.bham.ac.uk). Students should apply for one of three available projects, with a first year involving a range of interdisciplinary training across the University of Birmingham’s obesity research groups as well as development of generic, transferable skills. In addition, further training will strengthen their research abilities and specific skills for the named project, to which the subsequent 3-year period will be dedicated.
The available projects are:
“Examining ethnic differences in body fat composition and role of lifestyle factors in any variation observed among British school children” – primarily based in School of Health & Population Sciences
“Promotion of quality physical activity engagement in children: Assessing the effectiveness of a community-based project in the field” – primarily based in School of Sport & Exercise Sciences
“The regulation of lipid accumulation in human adipocytes by glucocorticoids and exercise in adults and children” – joint between School of Clinical & Experimental Medicine and School of Sport & Exercise Sciences

Although there are three projects available, we only expect to appoint two studentships.

Enquiries should be directed to Dr Eliot Marston (e.d.marston@bham.ac.uk)

Applicants should have a strong commitment to scientific research in the areas relevant to the project they select, and hold or realistically expect to obtain at least an Upper Second Class Honours Degree in a relevant subject.

These positions are funded for university fees and a stipend at competitive rates and are for EU nationals or those who meet the recognised residency requirement as detailed in the link above.

TO APPLY
Applications including a CV, names and addresses of two referees and a covering letter should be sent to Dr Eliot Marston, Research & Knowledge Transfer Office, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT or email e.d.marston@bham.ac.uk

For general studentship enquires, please contact Karen Carter (k.s.carter@bham.ac.uk)

The closing date is Friday 27th March 2009

Studentships available for the DPhil Programme at the University of Oxford

Science jobs from Gray Institute for Radiation Oncology and Biology: job description

Studentships available for the DPhil Programme at the University of Oxford
Gray Institute for Radiation Oncology & Biology

The Radiobiology Graduate Programme provides a fully integrated state-of-the-art research training environment. In addition to a theoretical course covering core and emerging areas of fundamental biology for oncology and its treatment by radiotherapy, the Programme engages students in high-quality basic and clinically-applied research, with the aim of training future leaders in radiobiology and radiotherapy for oncology. 4 year DPhil Studentships with an integrated MSc in the 1st year (subject to confirmation), are available to commence October 2009.

Projects are being offered in the following areas:

• REGULATION OF DNA REPAIR AND CANCER
Dr. Grigory Dianov
Reference H3-09-DP-GD

• IMAGING TUMOUR PHYSIOLOGY: SPECTROSCOPY AND MICROSCOPY DEVELOPMENT
Professor Boris Vojnovic & Professor Ruth Muschel
Reference H3-09-DP-BV

• INTRACELLULAR TRAFFICKING OF ANTI-CANCER DRUGS DIRECTED AGAINST ErbB RECEPTORS
Dr. Kate Vallis
Reference H3-09-DP-KV1

• CELLULAR DNA DAMAGE PROCESSING AND CANCER
Professor Peter O’Neill & Professor Boris Vojnovic
Reference H3-09-DP-PO

• REPLICATION FORK STALLING AT MAMMALIAN TELOMERES
Dr. Madalena Tarsounas
Reference H3-09-DP-MT

• BINDING OF miRNAs TO NUCLEOTIDE EXCISION REPAIR GENES IN BLADDER CANCER
Dr. Anne Kiltie
Reference H3-09-DP-AK

Further information on the available Studentships and the application procedure can be found on the Gray Institute for Radiation Oncology & Biology website at http://www.rob.ox.ac.uk

Closing date for submission of applications: Friday 13th March 2009.
Interviews will take place on 1st April 2009.

Don’t forget to mention Nature jobs when applying.

Science jobs from University College Dublin: job description

Science jobs from University College Dublin: job description

Ireland

funds great research…
…maybe it’s your turn!

Science Foundation Ireland, (SFI) the national foundation for excellence in scientific research is investing in academic researchers and research teams who are most likely to generate new knowledge, leading edge technologies, and competitive enterprises.

Current employment opportunities on SFI funded research projects

University College Dublin
Studentships Further Details:
http://www.ucd.ie/graduatestudies/prospectivestudents/studentshipsscholarships/

School of Agriculture, Food Science and Veterinary Medicine

PhD Studentship: Mucosal Glycobiology

Don’t forget to mention Nature jobs when applying.

Postdoctoral Research / PhD Studentship : Dublin Ireland

Science jobs from Trinity College Dublin: job description

Ireland

funds great research…
…maybe it’s your turn!

Science Foundation Ireland, (SFI) the national foundation for excellence in scientific research is investing in academic researchers and research teams who are most likely to generate new knowledge, leading edge technologies, and competitive enterprises.

Current employment opportunities on SFI funded research projects

Trinity College Dublin
Further Details:
http://www.tcd.ie/vacancies

School of Chemistry

Postdoctoral Research Fellow in Computational Chemistry

PhD Studentship in Computational Chemistry

Don’t forget to mention Nature jobs when applying.