Bioinformatic and data mining analysis of proteomic and microarray data from an explant model of articular cartilage inflammation
Applications are invited from students who possess, or expect to graduate with a first or upper second class degree and/or Masters degree in biochemistry, molecular biology, cell biology or physiology to work on a BBSRC CASE studentship in collaboration with the WALTHAM Centre for Pet Nutrition.
Articular cartilage degradation is the major cause of synovial joint dysfunction and disability in inflammatory osteoarthritis (OA) in ageing humans and companion animals. We are currently using in vitro models of cartilage to investigate the early stages of the disease and explore the effects of anti-inflammatories on inflammatory pathways and secreted biomarkers. This CASE project will apply data mining and network biology approaches to identify potential biomarkers of early OA development, with an expectation that this work will also provide insight into the response of chondrocyte to inflammatory perturbation. The successful student will apply proteomics, bioinformatics and microarray techniques to an in vitro model of cartilage degradation. The work will provide invaluable experience as part of the PhD training programme and will include industrial supervision from WALTHAM, a sponsor with an outstanding reputation in companion animal research.
Informal enquiries may be addressed to Dr A Mobasheri, tel: 0115 951 6449 or Email: Ali.Mobasheri@Nottingham.ac.uk.
Applications (preferably by Email), with a detailed CV and the names and addresses of two academic referees, should be sent to Helena Percival, Admissions Officer, School of Veterinary Medicine and Science, The University of Nottingham, Sutton Bonington Campus, College Road, Loughborough, Leicestershire, LE12 5RD. Email: postgrad-vet@Nottingham.ac.uk.
- Expires:
- May 30, 2009
