Science jobs from University College Dublin: job description
NB: this position is restricted to European Union candidates (EU status is based largely on recent residency – www.ucd.ie/registry/adminservices/fees/eu_fees.htm#2)
Are you interested in interdisciplinary research in mathematics, computing and biology?
New high-throughput technologies in biology have opened up exciting opportunities for numerate scientists to work in advanced areas of biological research. Our programme takes students from a variety of backgrounds (statistics, engineering, mathematics, computer science, biology, chemistry, physics) and gives them a structured training during their PhD, tailored to their needs. Each project is jointly run by two supervisors, one with a background in modelling or computational analysis and one with an experimental research programme. The student is integrated into the research teams of both research groups.
Applications are invited from EU students for 4-year PhD positions under the graduate education programme (GREP) of the Irish Research Council for Science, Engineering and Technology (IRCSET). Most studentships commence Oct 2009
Motif and domain determinants of protein localization in mammalian cells
Co-supervisors: Prof Jez Simpson UCD (Experimental protein subcellular imaging); Denis Shields, UCD
Co-localisation of proteins within cellular sub-compartments is critical for many protein-protein interactions, mediating cell signaling processes. But why do proteins go where they go in the cell? Our imaging methods allow the visualization of proteins, based on fluorescent tags attached to both the N and C termini. However, N- and C-terminally tagged proteins do not always go to the same location. This suggests that elements at the N and C termini may be important for localization of these proteins. In this project, the cellular distribution of proteins will be investigated in relation to the presence and absence of proteins domains, and of computationally identified terminal motifs (http://bioware.ucd.ie/slimfinder). A key question that will be addressed is whether particular combinations of motifs and domains play a role in specificity of localization and co-complex membership within the protein interaction network. Predictions arising from this computational modeling of protein localization will then be tested by experimentally visualizing the location of protein constructs with mutations in terminal motifs and domains.
Application procedure procedure and further details
http://bioinformatics.ucd.ie/PhD/apply_09.html
This studentship is funded by IRCSET (www.ircset.ie). Funds are available for a student stipend (€16,000), fees, some lab consumables ( up to €5,000 per year), and a travel budget to allow the student to get work experience abroad and industrial work experience in a company in Ireland or abroad.
Contact Details: bioinfo@ucd.ie
Closing date: 30th March 2009
University College Dublin
Website:
http://bioinformatics.ucd.ie/…
Location:
UCD, Belfield, Dublin 4
Expires:
May 15, 2009
